I am considering a TKI change and wanted to get feedback. I am currently on 100 mg Sprycel. I reached CCyR at about 14 months and, at my last appointment, my PCR was 0.3% and trending toward MMR. In addition to the constant rashes and fatigue, one of the big things I've noticed with Sprycel is that I get a lot more bacterial infections than I had previously. In the 6 months I've been on Sprycel my ANC has dropped from 3.6 to 1.4 (reference range 1.4 - 7.0). Now I seem to get a lot more sore throats, ear infections, etc., and it seems to be increasing as my counts lower. Overall it's manageable, but annoying.
My oncologist asked me if I was to assume that if I was to take Sprycel for the next 10 years would I have a good quality of life? That really got me thinking. He recommended I give Tasigna a try to see if the side effects are more manageable, but I know Tasigna has it's own set of issues including hair loss. I'm losing mine the natural way as it is and certainly wouldn't want to help the process along any.
If any of you have made this change I'd appreciate your feedback. Thanks!