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Iclusig and Methylprednisolone - the winning cocktail for battling CML and the skin side-effect, too?

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#1 tinman1939


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Posted 05 May 2014 - 09:30 AM

CMLers -

By now, some of you know of the skin issues I experienced with Iclusig - very unsightly welts or pustules on my face, ears and head.  My oncologist recommended a Methylprednisolone tablet pack (five days worth, or about 25 pills) the first time I had these skin issues.  Thankfully, the skin issues mostly cleared up within a day or two (of course, I finished my five-day pack). These tablets are  glucocorticoids, or adrenocortical steriods.  However, a few days after the steroid pill treatment ended, the skin issues resurfaced.  Again, I requested and was granted another five-day pack of the Methylprednisolone tablets.  But this time, after taking the requisite first-day dosage of pills, I cut back to two and then one a day.  Surprisingly and gratifyingly, the skin issues have not resurfaced.  Keep in mind I am only taking a low dose of 15mg of Iclusig daily.  But, combined with one of the Methylprednisolone tablets each day, this is keeping my undesirable skin side effect at bay.

My question now is: Is it safe to take one of these steroid tablets each day?  I wonder if there are any health issues related to that? I will ask my oncologist if I can somehow continue to get the Methylprednisolone tablet packs, but I am not sure that is wise or desirable.  Maybe there is an alternative treatment (e.g., a steroid shot) that I can receive at regular intervals to keep the skin issues at bay. 

I do know my oncologist wants me to ramp-up to 30mg of Iclusig a day.  I need assurance that my skin issues won't come back, however.  So, we need to get this issue resolved quickly.

Thanks for listening.


#2 hannibellemo


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Posted 07 May 2014 - 05:59 AM


I'm glad you have found some relief from your skin issues on Iclusig. Steroids are wonderful and will cure whatever ails you for the short term!    However, they are not without their side effects and they are not healthy for the long term. I was surprised to learn that some patients (generally cancer) are on 100mg/day or more for a year or two at a time, but it is generally necessary for their treatment.

Here is a link that may give you more information: http://www.patient.c...h/oral-steroids

Good luck!




"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>

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