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Is Anyone familiar with this study?


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#1 SUE

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Posted 25 April 2014 - 11:59 AM

I'm not sure if information on this study has already been posted.

I thought it sounded promising.

Sue

http://www.cancernet...e=1&ts=19032014


Dx  April 2013, FISH 62,  BMB not enough for PCR test; put on Gleevec 400;

 August 2013, FISH 8.7;

Oct 2013, FISH 5.6

Stopped Gleevec Nov 2013 for 6 weeks due to terrible side effects; Jan 2014 started Sprycel 50mg;

Feb, 2014 PCR  6.8

May,2014  PCR   .149

Aug, 2014 PCR    .015

Nov. 2014 PCRU

March, 2016  went down to 40mg Sprycel

Oct. 2016   stopped Sprycel for a couple weeks due to concern about shortness of breath.  Echo showed mild PAH.

Nov 1 2016  resumed Sprycel 20 mg daily 

Dec 2016  PCRU

March 2017  PCR 0.020

May 2017     PCRU

Sept  2017   PCRU

Dec    2017  PCRU

 


#2 Trey

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Posted 25 April 2014 - 08:09 PM

It is just supposed to be a more sensitive PCR (down to .0032% IS, which is 4.5 log reduction) to determine if the patient is truly in PCRU status.  Not sure that is much improvement, but maybe a little.  By the way, Dr Brian Druker is the founder of the company MolecularMD which is developing this PCR test process.



#3 SUE

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Posted 25 April 2014 - 08:25 PM

Thanks for the information, Trey.

The fact that Dr. Druker is involved seems like a hopeful sign.

Sue


Dx  April 2013, FISH 62,  BMB not enough for PCR test; put on Gleevec 400;

 August 2013, FISH 8.7;

Oct 2013, FISH 5.6

Stopped Gleevec Nov 2013 for 6 weeks due to terrible side effects; Jan 2014 started Sprycel 50mg;

Feb, 2014 PCR  6.8

May,2014  PCR   .149

Aug, 2014 PCR    .015

Nov. 2014 PCRU

March, 2016  went down to 40mg Sprycel

Oct. 2016   stopped Sprycel for a couple weeks due to concern about shortness of breath.  Echo showed mild PAH.

Nov 1 2016  resumed Sprycel 20 mg daily 

Dec 2016  PCRU

March 2017  PCR 0.020

May 2017     PCRU

Sept  2017   PCRU

Dec    2017  PCRU

 





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