Advanced Member
Posted 10 April 2014 - 03:45 PM
http://bloodjournal....5/2317.abstract
From the article:
"Most adverse events occurred by 2 years.
Imatinib-resistant/-intolerant patients with CML-CP can experience long-term benefit with dasatinib therapy, particularly if achieving BCR-ABL ?10% at 3 months."
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
New Member
Posted 11 April 2014 - 08:16 PM
I hope that's true. I took Gleevec for 18 months and plateaued steadily from month 12 to month 18, maintaining a PCR of about 2.5% (IS). After 2 months on Sprycel, it dropped to 0.1%
After experiencing an unforgettable and dreadful two-week-long headache when I began Sprycel, I experience far fewer side effects from it. I had all sorts of unusual side effects from Gleevec. For example, I had almost no sense of taste on Gleevec. My mouth was completely numb and I frequently bit my tongue and cheeks until they bled. The inside of my left check is all scarred up. That's a minor side effect in the grand scheme, seeing as I could barely feel it, but it was annoying nonetheless. It was really nice to get my sense of taste back. It returned within a week of stopping Gleevec.
Advanced Member
Posted 12 April 2014 - 06:46 AM
It seems like there are a number of us who switched to Sprycel, and had few, if any, side effects until about 2.5 years. That seems to be about the time that pleural effusions started happening. For myself, I had pretty much no side effects for the first 1.5 to 2 years. Then I got a miserable rash (though not so miserable that I couldn't live with it) on my neckline, scalp, and in my ears. A year after that came the pleural effusions (one bad, one mild). Reducing dose to 50 mg has helped immensely.
Sprycel has been great for me. . .50 mg even better. Be vigilant about pleural effusion. If your breathing seems funny, get it checked. And if you get it checked by a PCP, let them know that pleural effusion is a potential side effect. Took my PCP two weeks and two x-rays to decide it was pneumonia. . .even after I reminded her of the possibility of p.e.
Marnie
New Member
Posted 13 April 2014 - 12:52 PM
Swell.
How did you treat the rash? Prescription drugs like Prednisone, or OTC topicals like Hydrocortisone or coal tar?
See, I'm prone to tiny flair-ups of psoriasis once in a while, usually on my elbows. It appears it's a little more widespread and a bit harder to rid myself of the rash now that I'm on Sprycel, but this is the first flair-up that I've had on the new TKI. I am unsure it there's a connection.
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