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What is PCRU in international scale....


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#1 thomaskk

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Posted 10 March 2014 - 07:11 PM

Hi

I am bit confused about PCRU . What is that number in international scale. ?

Thomas



#2 GerryL

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Posted 10 March 2014 - 08:12 PM

Hi Thomas,

PCRU can be reported as 0.000 or negative as my hospital does.



#3 Trey

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Posted 10 March 2014 - 08:56 PM

Zero is universal, not international, no matter how it is calculated. 

Just don't try to divide by zero.  This gentleman tried it, and look what happened.  Very sad.

PhilB2.png

Hey, is Herodotus back in England?  Is he waving?  Why, that little bast......



#4 CallMeLucky

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Posted 10 March 2014 - 11:17 PM

PCRu can also be referred to as Complete Molecular Response (CMR) which is considered > -4.5 log reduction


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#5 hannibellemo

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Posted 11 March 2014 - 03:31 PM

Damn it, Trey, I was taking a drink of water when I read your post. You obviously have too much time on your hands.   My poor monitor!

Pat


Pat

 

"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>


#6 Marnie

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Posted 11 March 2014 - 08:58 PM

Makes me want to play around with photoshop.  Dang.  If only I had some time on my hands. 

I'm starting to wonder if that darned squirrel that dug up all of my tulip bulbs, then got into our walls (dumping my bulbs there and driving our cats crazy with his scampering up and down inside the walls) was the pictured rodent.  He has the weaselly eyes and villainous expression on his face. . .oh wait. . .maybe I'm confusing him with the guy with mustache. 



#7 Trey

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Posted 12 March 2014 - 09:15 PM

Have you checked on your bike lately?

BMW herodotus.jpg



#8 Tedsey

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Posted 13 March 2014 - 09:57 AM

My lab reports CMR as <0.001 and states that is the limit of the test.  0.000 is never reported.  I suppose that is realistic.  As we know too well, even at zero, there are still leukemic cells undetected. 

On another note, I don't believe Chicago will ever thaw enough to have squirrels dig up my bulbs.  We seem to be in an eternal winter (today it is 14F / -10C).  Now I understand why they send the bad guys to Siberia.  What were the Brits thinking when they sent their criminals to Australia?  I can see why they changed their minds and then populated the state. 



#9 simone4

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Posted 13 March 2014 - 10:57 AM

Tedsey, I thinkof you every morning when I watch "The Weather Channel" (best show on TV

and based here in Atlanta).  How in the world have you endured this? Chicago has been hit

so hard this year, as well as the rest of the Northeast and Midwest.  I think of you all and

wonder how you manage every day life with so much snow and ice.

I'm glad you gave a window to express my concern.  Hoping spring will come

at least by May.

Simone



#10 Marnie

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Posted 13 March 2014 - 06:34 PM

When I have time, I will photoshop a helmet onto that poor squirrel.  I firmly believe in ATGATT (all the gear all the time).  Speaking of tulip bulbs, Tedsey, my first crocus just came up.  And as I was walking back into the house, I saw the first dandelion as well!!!!!  Denver goes from winter to spring in a matter of minutes.  Quite a bit unlike my native Minnesota.  I remember one year when the snow was up to the roof of our house, so we brought the sled inside, climbed out my bedroom window (second story) onto the roof of the garage, and slid down to the ground on the sled.  And I remember walking 12 miles in hip deep snow to get to school every morning. . oh wait a minute. . .that was my grandmother.



#11 Tedsey

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Posted 14 March 2014 - 11:50 AM

Thanks Simone.  I have to endure the deep freeze every morning and afternoon when I have to stand outside to drop off and pick up my first-grader at school.  The school used to let the kids right in, but at this point, I guess they figure we are all "hardened" and the kids can stand outside in line in -0 temps.  My toddler is crying for spring.  I don't blame her.  I feel like we are stuck living in that new Frozen movie.  It has been tough.  Long underwear and snow pants help, but you cannot stay out very long.  I, woman of 1000 shoes, am very tired of wearing the same ol' snow boots day in and day out!  My cute new boots are now worn out!

This morning was a whopping 45F!  Simply tropical!  I saw some brave souls without hats!

Take care!



#12 PhilB

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Posted 14 March 2014 - 01:08 PM

PCRU = 0.000 - looks something like a row of bullet holes.  Such as the ones in Trey when my little friend catches up with him

untitled.png



#13 Jamar

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Posted 17 March 2014 - 04:00 PM

Are you in Chicago?

My onc is at University of Chicago. They just switched to the international scale which confused/scared the hell out of me when I got my latest results.






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