I am on 100 mg Sprycel and my last PCR was 0.5% IS after about 15 months of treatment. My last FISH was 0% so I've achieved CCyR but, overall, I have had a slow response. Recently we had some heavy snow in our area which unfortunately delayed delivery of my meds. So I've been off of drugs for four days now. I feel fine but yesterday when my son was holding my hand I noticed it felt sore which was strange for me. I don't remember hitting it or anything although I did have to do a good amount of shoveling recently. Now this morning I've got a pretty noticeable bruise between my thumb and forefinger. Never had a bruise there before in my life so I'm not sure what to think. Would you consider a four-day drug break enough time to result in changes in blood counts or give CML an advantage? Last time I stopped treatment, to go from Gleevac to Sprycel, my PCR shot up pretty quickly but later dropped back down. I'm right at the 18-month timeframe so concerned that this is pretty bad timing for something like this to happen. My Sprycel should arrive today so I'll get back on it right away but thinking my next PCR in a couple of weeks will not be great. Considering reaching out to my Onc before then. Appreciate your feedback.