I was curious to know if anyone has ever switched back to Gleevac after trying one of the other TKIs.
I was on Gleevac for about a year and decided to try Sprycel mainly due to some abdominal issues. Overall the issues were pretty tolerable and didn't impact me too much but wanted to give Sprycel a try to see if the issues would go away and if I might respond better to Sprycel. WIth Sprycel I notice that I have essentially the same abdominal issues but also have a persistent rash and occasionally get chest pains as well.
My last PCR on Gleevac was 1.06% and after 5 months on Sprycel I'm down to 0.5%.
Is there generally any issue with switching back provided that the PCR continues to trend downward? Would this in any way give the disease an advantage or potentially contribute to mutations?