I came across an interesting article on augmenting cancer therapy with polyphenols (plants) such as Curcumin.
I am back to my original 20mg per day Sprycel. Along which I take 8 grams of Curcumin. But I also eat Broccoli every day (I just like it - especially crunchy).
I am borderline PCRU at last test (0.003) in which I was told I am below the detection limit of 0.01, but they still gave a number. Dr. Cortes told me that if I wanted to reduce dose to 20mg, to go ahead. He expects my response to be the same as what I had at 40mg. He is a strong believer in lowering dose if lower dose works. So I decided to go back to my old dose since the higher dose didn't change anything. On 40mg. I had "sensations" - can't quite say side affects, just that I noticed my heart/lungs more when lying quiet. On 20 mg. - nothing. I continue to ask him if the Curcumin is enabling the lower dose to work as good as a higher dose. He told me - "could be - we don't know without trials". So I am my own non-scientific trial. I would have to stop taking Curcumin to see if I hold my response on just 20mg. But Curcumin has been terrific for joint pains - I no longer have any and is otherwise good to have in the body vs a toxic TKI. So - long term - it's 20mg. Sprycel plus Curcumin (8 grams).
I am coming to the end of my personal dose experimenting. The only thing left is to stop taking Sprycel altogether and see if my MMR stays the same. I'm getting close to making that decision, but need permission to have a PCR test at six weeks instead of the normal three months. I would want to catch a relapse as soon as it were to appear. There is a huge psychology to PCRU even though we all know it's not a cutoff, just a limit of detection. I wonder how many people (Chris C comes to mind) who are PCRU, still have a positive PCR if the test were more sensitive (a few more decimal places) and have also been drug and disease free. Maybe 0.01 is sufficient for some. Every three months I get so close to just stopping and see what happens.