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Tasigna Side Effects - Blocked Ears & Runny Nose

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#1 CDW


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Posted 05 January 2014 - 10:28 AM

Happy New Year All,

i've been on Tasigna now fro 3+ years. I'm experiencing constant runny nose (drainage) and also have a blocked ear for 6+ months - fluid retention behind my ear drum. Has anyone else experienced this on Tasigna or Gleevec?

Just trying to work out if it's a side effect or an unrelated issue.

With thanks


#2 Ray99


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Posted 05 January 2014 - 01:02 PM


   I have been on Tasigna for about 21 months.  I did experience frequent running nose, especially when outdoor, but not constantly.  Do not have blocked ear problem.

Hope this helps.


#3 Trey


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Posted 05 January 2014 - 05:03 PM

My ear canals are more restricted, which I assume is a soft tissue edema.

#4 janne



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Posted 05 January 2014 - 08:16 PM


Have been on Tasigna almost 3 years and have had a runny nose most of that time. At the moment, I cannot identify exactly when I do not have it but there are times when it is not occurring. I had meant to post a question in regard to this also but never got around to it. I do not have seasonal allergies and there are no other symptoms associated with it. I cannot really identify any ear plugging sensation associated with it. Thanks for posting.

Dx'd: 8/2008. Started Gleevec 400 mg 11/08. 

Drug break 2011.

Started Tasigna 4/11 450 mg.

Reduction to 300 mg Tasigna 1/2012.

PCRU 9/2012.

12/2012 Detectable.

PCRU 4/2013 through 3/2015. (Reduced to 150 mg 7/2014)

12/2015  ? slightly detectable at probably less than 0.01% per Mayo Clinic.

4/2016 PCRU. Still at 150 mg Tasigna.


CESSATION: stopped treatment 7/20/2017. 

9/6/2017:  barely detectable at 0.01%. 

12/11/2017: PCR at 0.09% (did not do the monthly PCR testing.) 

12/18/2017: Inevitable call from Onc. Started back on Tasigna at 150 mg. (Considering Sprycel low dose.) 

#5 kendavies


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Posted 06 January 2014 - 03:15 AM


Our 37 year-old daughter, (dx 2008), has experienced these two side-effects on both Gleevec and Tasigna. Overall, edema is the biggest issue with which she has to deal. Lasix helps greatly but has its own side-effects problems.

#6 cleocans


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Posted 06 January 2014 - 07:33 AM

I am on 100 mg Sprycel and I have the blocked ear problem.  It is worse in my left ear though.  I also have constant stuffy nose.

#7 hannibellemo


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Posted 06 January 2014 - 01:31 PM

I also have had sinus issues on Sprycel, but not so much now that I am on 50mg. dosage.



"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>

#8 CDW


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Posted 07 January 2014 - 02:55 PM

Thanks for your input, although it sucks that we have these issues, there is cold comfort in knowing it is likely the TKI influencing the problem rather than something else. I have found when at the beach (preferably warm) that my runny nose stops. As for the ear...that really is a pain.

Thanks again and best wishes for 2014


#9 tazdad08


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Posted 08 January 2014 - 02:20 PM

I was on Sprycel for 14 months, off TKI's for 6 weeks, then Tasigna for 10 months now.... No runny nose... but my wife really thinks that my "selective hearing" has gotten worse. Maybe the TKI's are to blame. I am only 42 and never had hearing issues before.

Diagnosed in September 2011. Tried one year of Sprycel. Had great response. Became undetectable in a few months. Changed to Tasigna hoping for less side effects. Self medicated myself down to 20% dose and held for 3 years before becoming detectable again. It has been a journey that has helped me realize what life is about! I am all about a balanced life. I firmly agree with my decision to lower my dose. What is life if you aren't living? Mine will never be the way it was, but it is going to be as good as I can make it! Drs PRACTICE medicine, we can guide our dr to help us with a better life! Don't settle until it's acceptable to you!

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