Just got my latest test results and would appreciate feedback. I am 16 months into treatment and am currently on 100 mg of Sprycel.
FISH test showed the following result. I am not sure exactly how to interpret this.
200 interphase nuclei were scored following fluorescence in situ hybridization (FISH) with a D FISH probe specific for fusion of the ABL1 oncogene and BCR (breakpoint cluster region).
This result is within normal limits.
Interpretation: This result is within normal limits (< 1% of nuclei with fusion).
My PCR results over the last several tests are pretty concerning to me. (You'll note that I've had tests done at several different labs recently as I've been seeking additional opinions.) All are IS Scale
1 year (Quest) - 1.062%
14 months (Genoptix) - 0.9272%
15 months (Quest) - 0.608%
16 months (Johns Hopkins) - "The expression level of BCR-ABL transcripts is equivalent to 3.8 copies per 1,000 copies ABL (International Standard 0.8% BCR-ABL1 to ABL1 ratio).
So I assume that my last result is 0.8% although I'm confused how 3.8/1000 translates to 0.8. Would appreciate any feedback on this.
It just seems that I have had a much slower response than many people and I'm concerned about the last result. i was really hoping for a better response, but after four months on Sprycel I can only show an improvement of 0.2% in my PCR and my latest result seems to have increased.
Feedback is appreciated. Thanks.