I received my 3 month PCR test results from M.D. Anderson.
No change from last test. I am borderline "undetected" at 0.003. Three months ago I had the exact same result.
Limits of detection I was told is 0.01 meaning that this result is merely that there was a bcr-abl protein blip and rather than report a "zero", they report a number. They could have easily reported it as "zero".
Dr. Cortes told me that I could reduce my Sprycel dose back to 20mg from my current 40mg if I want. He expects that I will continue at this residual level for some time and will eventually fall below any detection.
I'm tempted to stop Sprycel altogether and see if my PCR number stays flat, but I would want to be re-tested at six weeks, not 3 months. If the CML clone is going to expand, I prefer it only have a few weeks to grow drug free before I bombarded it again with Sprycel. But then - it would be interesting to see if my body has managed a way to keep the disease in check as the normal population.
20mg or 40mg doesn't seem to make a difference in my case - so I will probably return to my 20mg. dose. Less drug, less toxicity, less unseen side affects. Worst case - my PCR number goes from 0.003 to 0.006 or 0.01.
So damn close to the magic number.