I'm seeing that there are a fair number of newly diagnosed CMLers on the board. I'm writing for the newbies. I was diagnosed in August 2012 and it has taken me 15 mos to feel like a human being on therapy. I am fortunate in that a) my meds work on the CML and no life threatening side effects. Unfortunately, I've had many of the pain in the tail side effects. My most problematic effects have been marked fatigue and tendon/joint pain. For the fatigue, I've changed meds and reduced dosages. The reduced dosage Tasigna has helped both the pain and fatigue. I have found that instead of working 60+ hour weeks I have to work 40. Reducing my work hours was a tough call but it has helped immensely. Never in my life have I required this much sleep (9 hours at night with a 1 hour nap after work), but this is what it takes, now. The better I eat, the better I feel (less processed, lots of fruits/veg and whole grains). Daily exercise in a hot tub twice a day helps with the pain. Doing all these things has helped me finally feel human for two full weeks now.
For the newly diagnosed folks on the board, my point is that finding what works for you is trial and error. Your treatment team can help you with med adjustments but the non medical part is just as important for your sense of well being. Some benefit from heavy gym work outs whereas others of us find that wipes us out for the day. What works for one person may be awful for another. Just keep trying strategies, see what helps and build from there. It does get better, but it takes time and work to find a tolerable new normal.