I was diagnosed CML 8 yrs ago. Glevec (failed) Sprycel (severe pleural effusions). Been on Tasigna last 3 yrs (PCR never neg. and developed diabetes which I can not take diabetes drug for because they cause really low blood sugars). I'Ve been on "drug holiday" due to side effects for 10 weeks. Latest PCR last week there was a considerable 3% rise and Dr. said I have to go back on either Tasigna (which causes diabetes in me) or switch to Bosutinib (which will mean going off a major blood pressure med I have taken for years). I would so appreciate anyone's input. I have never been so discouraged, since I was diagnosed, as I am now.