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PCR resumed to drop after a long plateau


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#1 Ray99

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Posted 04 November 2013 - 10:09 PM

My PCR dropped to 0.23%IS in the first 4 months since starting Tasigna 19 months ago.  It then stuck between 0.3% and 0.1% for the following 11 months.  I was worrying about the stalled response and thinking about switching drug.  Many of you on this board suggested that I should stay the course for another while. 


Two months ago, it dropped to 0.046% and I was happy and wondered whether it would last.  The result from last week is 0.062%.  It ticked up a little, but still a solid MMR.  I hope that it will bounce a little around this level and  begin to drop again, fingers crossed.



#2 Melanie

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Posted 06 November 2013 - 04:47 PM

Ray, that's great news! Shows that even slow responders can continue to gain a deeper response if we can just wait it out. Thanks for sharing...very encouraging and congratulations! 


Dx - 05/2011; PCR: 15.04; Fish: 87% Slow responder due to pancytopenia. Current - Bosulif - Nov: 2012, Mar 2016 lowered to 300 mg. 07/16 back to 400 mg. Clinical trial drug, Promacta, Feb 2013, for low Platelets.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)




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