Janine - Readings below 0.01 are subject to all kinds of errors and "false positives". It is a very low level of disease detection. It is very likely that you have had no increase at all and the lab result is just noise. But it could be a real increase albeit a small one.
To be prudent, you could wait until next test and see if your level continues to rise or if you fall back into 'undetected'. Undetected, by the way, is CMR (complete molecular remission).
However - you could also do an experiment and stop taking your drug as you have planned and test again after six weeks to see if your result is the same. A low residual level (pcr < 0.1) which is MMR is emerging as a candidate for drug therapy interruption - not just CMR (PCR < 0.01).
CML is a slow disease when it is at this low level (with low blasts). The risk of dangerous disease advancement by stopping your drug is very low. In my view the risk is near zero when PCR's are below 0.01. Look at all of us who have drug interruptions for weeks and weeks (in my own case, I had a drug interruption for 3 months and not only was my PCR > 50%, my FISH was greater than 50%) with no issues whatsoever once our drug was re-introduced. In many cases disease remission resumed.
If you are comfortable with risk - then you could try the stop drug routine. But if you are uncomfortable and your doctor is not willing to guide you along, then you may have to just stay on the drug.
Hope this is useful
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"