Hello all! Just wondering if anyone else is having a slow response time and what the prognosis is. It's actually been 2.5 years post dx and I still have 3ph+ chromosomes. Really not all that unexpected considering I've had many TKI interruptions and never able to take full dosage of any TKI due to low counts. Presently on Bosulif, neupogen shots, and clinical trial of promacta (for platelets) and have been able to stay on the TKI at 60% of full dosage for 9 months now, but I've been stuck at 3PH+ on my last two BMB. Local oncologist says there's just no data to know what to expect in this situation since TKI treatments are fairly new. Old days prognosis for CML was 3-7 years, but does the TKI treatment slow that down when there's been some response...though not CCyR? Typically the milestone is 18 months for CCyR...not much is said about what happens when that goal isn't achieved. I'm being encouraged to consider SCT because of my age (59) risk and because they just don't know what to expect and of course it's a last resort. Am I at that last resort point? I'm feeling quite well... Any conversation would be welcomed...it's quite the quandary.