Hi fellow CMLers! I stumbled upon this site yesterday and so glad I did! I have spent the whole day reading threads, and I have a question of my own I could use some help with:
I was diagnosed 6 months ago, CP, and have been on dasatinib on and off ever since due to low platelets. Achieved CHR quickly, but at 3 months I had minimal cytogenetic response and no drop in PCR. Will have BMB again in a couple of weeks but not very hopeful as I have been off dasatinib about half the time and if all goes well only 3 weeks on it at 50mg immediately before the BMB. (I'll save the interruptions/dosing issue for another discussion) At diagnosis and also at 3 months about 1/3 of the Ph+ stem cells were also -Y (missing Y chromosome). I have been told this can happen in older men, but I am only 27! My onc is worried this may be the reason for the myelosuppression, as maybe my "normal" stem cells are also -Y (no evidence of this yet) and slow to repopulate, and thus a BMT would be necessary. I speculate that since I was diagnosed fairly late (300 WBC, spleen huge) it could just be plain garden variety myelosuppression, which is bad enough I guess. According to articles I've read, the jury is out on significance of -Y, but not a good sign for sure. I am interested if anyone has any knowledge or even first hand experience of -Y and its impact on low counts/slow response?