I was diagnosed with CML in August of 2012. I was put on Gleevac 400 mg. After 7 months on Gleevac my PCR was 5.55%. At 12 months it was at 1.06%. Around that time I started having a lot of GI issues. My oncologist recommended that I try stopping Gleevac therapy for two weeks to see if the symptoms subsided, which they did. I had the GI issues checked out and had a CT scan done, and all came back normal. Following that I switched over to Sprycel. I think I was off the TKIs for just over two weeks. I had another PCR test after being on Sprycel for about two weeks and my PCR was up to 3.7%. So in about one month my PCR rose 2.7%, but for two weeks of that time I had discontinued TKI therapy. I have another PCR test in 6 weeks to follow up on this result.
All other bloodwork is normal including CBC, CMP, and LDH. Of course I am really concerned about the increase in the PCR. Does anyone have experience with stopping therapy and PCR results such as this?