I had my three month blood test today at M.D. Anderson.
I am waiting on the PCR results (next week), but I thought I would relay the CBC results since my protocol was changed.
At last test three months ago, I increased my Spyrcel dose from 20mg. to 40mg. There was a concern that I could re-introduce severe myelosuppression again.
Some of you know that I had been on 20mg. Sprycel and barely had my Neutrophils in the normal range at that dose. They hovered around 1.4-1.5 (which for me was great!).
We decided to give 40mg. a try and see if I can nudge my PCR into undetected and not lower my Neutrophils too much. I am a candidate for "cure" trials if I can get to PCRU.
Well ... surprise surprise.
After 3 months at double dose (40mg.), my Neutrophils went up and are now solid normal (2.5). In addition, my platelets went up and they are now in the normal range.
Only my red blood cells continue to be suppressed (along with hemoglobin) at 3.5, but not too bad.
Also, in the last 3 months, I decided to change my diet to plant based (although I sneak in a steak once in a great while), no refined anything except fermented grapes and I run 2.5 miles a day (lost 15 pounds).
I think less about CML now, and more about heart, arteries, general fitness which is probably a good thing. We're told over and over that we'll die of something else, not CML. I believe them.
I am pleasantly surprised at the Neutrophils not tanking. I look forward to what the PCR result comes back. It will be a tough decision to lower my dose if the new dose at 40 mg. puts me into PCRU territory.
p.s. I do feel the 40mg where I never felt the 20mg Sprycel. At 40mg, my heart pounds a bit more at bedtime, two hours after I take the double dose. It fades away two hours after that. Taking 20mg. Sprycel never did that. So I would still like to go back to 20mg if it turns out 40mg. didn't drop my PCR.