Marie, Been on Gleevec since 2005 also started out on Hydrox for a short time. My eyes and face swelled up so bad I could barely see. They don't swell anymore, but it sure left me with baggy eyelids. I think of having plastic surgery sometimes but at 65 years old and Kidney GFR at stage 3, well I am afraid something might go wrong, infection of something. I did talk to a plastic surgery, and it takes a long time to heal and you really have to be extremely careful. I have been on blood pressure meds' and a diuretic since 1997 and I am quite sure that is why my GFR is stage 3, that means the kidney filters are damaged. I am vitimin D deficient and very low in Vit b12. My new primary doc has ordered labs for next week to check a lot of other things. I am probably low on a low of things as the kidneys control a lot of stuff like processing vit D, your electrolytes, thyroid, blood pressure, etc. I think Kidneys are the main organ. Most doctors don't seem to worry about it to much as they just seem to slough it off as to "oh you can live on a dialysis" what kind of answer is that? AT 65 years old and my life pretty much gone, why would I want to add a dialysis to cancer (CML), dang, most people get infections on the dialysis and it is tricky. However I lost 35 - 40 lbs and rarely do I take any blood pressure meds or diuretics. I started taking the blood pressure and diuretics in 1997. The diuretics weren't given to me for fluid or swelling but as a blood pressure med, lots of docs do that. two cardio docs warned me not to take them as it is hard on the kidneys unless of course you really need them when your lower legs, ankle, feet swell, which mine have never been swollen, just my hands now then because of arthritis, but after a day they go back down. I am hoping since I have taken diuretic for sometime now, that my GFR will be better next time. I don't know if the kidney filter are permanently or temporary damaged. I also keep a eye on my Creatine, Bun, electrolytes, etc.