Once the doctors has the results of the mutation test they will determine which drug to use next.
I have been on Gleevec (failed because of a mutation), Sprycel (did not work for the mutation I have F317L), 3 plus years on Tasigna (never reached undetectable), now Iclusig (because of the F317L mutation). I have been on this drug about 90 days, 45 mg per day. Everything was fine for about 2 weeks. Then the pain started, lasted about 3 weeks. For the last 6 or 7 weeks no pain and from the start, June 20, until the last PCR test about 60 days after starting Iclusig, my numbers on the IS scale, have dropped from 10% to .0191%. Next PCR test is in 11 days.
I started on the highest dose of Iclusig. I have heard that others have started on less of a dose so their bodies get accustomed to the drug. That would be my suggestion from my experience, but I am no doctor. You will need weekly blood tests for the first month, from company website. Then for the next 2 months the test are every 2 weeks, again my experience. Hopefully in 11 days the results will be good enough that I can go back to once a month (or every other month), arms are getting beat up from getting stuck so much.
If you start taking Iclusig make sure they monitor your liver, kidney, and pancreas numbers. I found out my pain was caused by my pancreas swelling which has since gone away. Make sure you get a pain medication just in case.