My husband was diagnosed in August of 2009 with CML and put on Gleevec 400mg. Because we were unhappy with our oncologist and felt he wasn't knowledgeable enough with the CML "benchmarks" we switched to Dr. Talpaz at U of M. They did the normal testing and found that my husband had a suboptimal response to Gleevec since after 4 years his PCR still showed 2% on the international scale. He made the switch to Sprycel just over 3 weeks ago. He has had the "normal" side effects with fatigue and such but has complained about heart palpatations and occasionally a rapid heart beat. It isn't constant and he doesn't have shortness of breath or any chest pain. We called Dr. Talpaz and they did labs to check his potassium levels (his runs low so is on a potassium supplement), EKG and chest xray and all came back normal. Is this just something that is going to run it's course or do any of you have the same symptoms and have normal results from cardiac tests?