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Sprycel heart rate/palpatations

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#1 ashleyking51907


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Posted 29 August 2013 - 03:03 PM

Hello all!

My husband was diagnosed in August of 2009 with CML and put on Gleevec 400mg. Because we were unhappy with our oncologist and felt he wasn't knowledgeable enough with the CML "benchmarks" we switched to Dr. Talpaz at U of M. They did the normal testing and found that my husband had a suboptimal response to Gleevec since after 4 years his PCR still showed 2% on the international scale. He made the switch to Sprycel just over 3 weeks ago. He has had the "normal" side effects with fatigue and such but has complained about heart palpatations and occasionally a rapid heart beat. It isn't constant and he doesn't have shortness of breath or any chest pain. We called Dr. Talpaz and they did labs to check his potassium levels (his runs low so is on a potassium supplement), EKG and chest xray and all came back normal. Is this just something that is going to run it's course or do any of you have the same symptoms and have normal results from cardiac tests?

#2 triciad


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Posted 29 August 2013 - 04:59 PM

Hi Ashley-

I was on Sprycel for over 2 years and had occasional heart palpatations the entire time until I switched to Tasigna 4 years ago due to PE.  I was so worried about the palpatations at first that I saw a heart specialist who put me on a monitor and then diagnosed me with supraventricular tachycardia.  No one ever said it was due to Sprycel but I was only 42 at the time and had no problems before when I was on Gleevec.  They put me on a mild beta blocker which didn't help much so I just lived with it. 

I've been on Tasigna for over 4 years and recently just started getting them again.  They don't seem to be as bothersome and are only at night.  Sorry I don't have answers for you but wanted you to know I experience them too. 


#3 Taylor



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Posted 31 August 2013 - 09:52 AM

I had some issues on Tasigna, which included PVC palpitations. They were worst upon exercising and I also just seemed to notice my heart was beating quicker than it should. After a 30-day monitor my doc put me on a beta blocker and, after an episode of a-fib, prescription potassium.

The Rx potassium has done wonders for the palpitations and other things like cramps.

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