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Can dasatinib or imatinib cause diverticulitis?

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#1 cousineg


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Posted 01 July 2013 - 07:58 PM

After two months of imatinib (600mg), I took 5 days without medication. Then I started dasatinib. The next day, I have to go to emergency for diverticulitis. Simple coincidence?

What is diverticulitis?

Diverticulitis occurs when small pouches (diverticula) commonly found in your large intestine become infected or inflamed. Diverticulitis is especially common after age 50 and symptoms can range from mild pain, fever, and nausea, to life-threatening infection


Diverticula are sacs formed by a fold of the lining of the intestinal wall. They extend through the muscle surrounding the bowel, and occasionally trap feces moving through the intestine may divert into them and become trapped. Diverticula are extremely common and usually harmless. They tend to appear after age 40 and are more likely to appear in seniors.

Diverticulosis is the condition of having one or more diverticula. Usually there are no symptoms or problems associated with this condition.

Occasionally, diverticula become inflamed. If you have one or more inflamed diverticula, you are diagnosed with diverticulitis. The word ending "-itis" means inflammation. Diverticulitis can be a serious condition.

Diverticula often appear in bunches. Each is typically less than an inch in diameter. Rare giant diverticula can be up to 6 inches in diameter, and always appear alone.

Diverticula can also appear in the gastrointestinal tract above the stomach, in the esophagus. In these cases, it's food rather than feces that may get trapped. Esophageal diverticula don't cause dangerous problems, but a few people find that trapped food comes back up when they bend over or lie down


#2 Pin


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Posted 07 July 2013 - 08:51 PM

I have definitely read that this was a possible side effect of imatinib - not sure about Dasatinib though.

Diagnosed 9 June 2011, Glivec 400mg June 2011-July 2017, Tasigna 600mg July 2017-present (switched due to intolerable side effects, and desire for future cessation attempt).

Commenced monthly testing when MR4.0 lost during 2012.


2017: <0.01, <0.01, 0.005 (200mg Glivec, Adelaide) <0.01, 0.001 (new test sensitivity)

2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)

2015: <0.01, <0.01, <0.01, 0.013

2014: PCRU, <0.01, <0.01, <0.01, <0.01

2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01 

2012: <0.01, <0.01, 0.013, 0.032, 0.021

2011: 38.00, 12.00, 0.14

#3 Cliffee



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Posted 08 July 2013 - 01:43 AM

Do you drink a lot of soda? Do you eat a healthy diet with plenty of fiber?

Soda causes this and eating fiber helps prevent it.

#4 Tom_H


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Posted 11 July 2013 - 04:05 PM

Shortly after I was diagnosed and put on Gleevec, I developed diverticulitus. (Fairly mild but pretty painful) It had run in my family, so I was not convinced that it was Gleevec related.  I mentioned to my Onc during one of my visits when he asked how I was doing, and follwed it up with that I doubt it was related to CML/Gleeevec and he said he would not be sure of that.  That was about 4 years ago.

I have not had any flare-ups for a while several years.  I have increased my fiber intake, also have been on lower dose Gleevec, so I am not sure what led to the improvement.

Hope you feel better soon.

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