So, I just have a quick question because I want to get some opinions. I am about 27 months past DX. I was on Tasigna, I had a flat response on PCR for over a year. Anywhere from 1-3% IS Scale (Tests done at U Mich, not my normal hospital). About 7 months ago I went to U Mich to see Dr. Talpaz. He suggested 70 mg Sprycel. I started that and have had some success. On my PCR test at my regular hospital I went from a .9 log (0.20% against the control gene) reduction at the beginning of Sprycel to a 1.5 log (0.069% against the control gene). I know this isn't exactly speedy, but considering my PCR didn't move for over a year, I'll take it. However, I am wondering if I am short changing myself because I am not on 100 mg of Sprycel. I have almost no side effects so I believe I could tolerate more drug. My WBC usually hovers around 3.8-4.3 so a little low. How would you apporach your oncologist about this? I know mine will say "We'll we've established a trend with the 70mg, so why change". Thanks for the feed back.