I have a question - Started Gleevec
* diag 4/12
4/12 -pcr at diag - 105%(IS - I converted it from non IS)
7/23/12 pcr 100% slight -0.0256 log reduction(Blood cleaned up Nicely)
9/4/12 pcr - 27.32%(IS) -0.56 log reduction
Started 100mg of sprycel with reduction to 70 mg with two drug breaks totaling 8 weeks between the two pcr dates
2/15/13 pcr 2.34%(IS) -1.63 log reduction
My question is I found out my FISH(from Bone Marrow NOT Blood) was 20/20 on 2/15/13 at the same time I had a -1.63/-0.54(Blood/Marrow) log reduction. Both test were taken during a recent 5 week drug break. How can the blood PCR going in the right direction but the FISH in the wrong direction occur.(I am sure blood and marrow are different and the drug break did not happen. How close in general are the Marrow and Blood PCR numbers?
I am definitely a slow responder but the Onc who specializes in BMT, I finally talked onc down to 50 mg of Sprycel(the next dosing if Blood keeps tanking) but no lower but wants to begin the BMT process at my next apt on April 1. Also, I made it clear and onc. concurred, plans are no more drug breaks, I am ready for the shots and Platlets to keep my ANC and Platelets up.
I also have an apt with Dr. Talpaz on April11(My 1 year diag. anniversary - opefully a good Omen), thanks to CallMeLucky suggestion and Dr. Talpaz has written to me and says his plan are accomplished with no BMT.
Any Questions or Comments are appreciated.