This looks very interesting, too bad they aren't doing it in US. One thing I am taking from this is that the doctors running the trial do not appear to be too concerned about low dosage causing resistance. I also thought the hypothesis that some CML patients are being over treated was an interesting way to look at the current state of treatment protocol. I know it will take some time but definitely looking forward to seeing what they find out.
Posted 10 March 2013 - 03:14 PM
Posted 10 March 2013 - 03:17 PM
I read a bit about the Destiny trial at a UK CML forum earlier, but there wasnt much info on it. Link much appreciated, thanks.
Glad to see they are accepting people who are MMR and MR4, and not just those who are MR4.5.
Posted 12 March 2013 - 04:02 PM
I just had my 3-month blood draw today at M.D. Anderson. This time they took 7 vials to test for general health (glucose, lipids, thyroid,metabolic,etc.) in addition to bcr-abl (PCR).
I am a de-facto low-dose trial. I have been on 20mg. Sprycel now for over a year and have been trending down in PCR to where my last test stood at 0.001 or so. I am so hoping that my current test shows PCRU. I believe I will be the only patient at the Center on 20mg. who achieved PCRU this way. Dr. Cortes definitely feels that many patients are over-treated. I want no treatment! If I can stay at PCRU for six months (two test periods) while taking Curcumin, I will stop and see if I become positive again in six weeks time. There is emerging evidence that Sprycel messes with Osteocytes (causes them to differentiate into fat instead of bone). A fatty bone marrow is not good for long term health.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
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