It is difficult to tell from your previous posts whether you acually failed to maintain a response with Sprycel (you had a very good response at one time according to your post) or switched to another drug because of side effects. Depending on what the kinase mutation test shows, if it's the latter I would reiterate what Trey said and try Sprycel at a lower dose.
I have been on 50mg. of Sprycel for 10 months after a pleural effusion developed at the 100mg. dose. The reduction has worked very well for me. I was off anything for almost 10 weeks and lost my MMR status. My last PCR showed that I was .2% IS so I'm almost back there - I tend to be a tortoise with TKI response.
Don't worry about PCRU, that's icing on the cake! What you want is to get down to 1% IS (CCyR) or lower and maintain it!
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>