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Half-dosage and half life

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#1 Taylor



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Posted 24 February 2013 - 02:56 AM

I was reminded that I'll go see my onc next month and I believe we'll do a PCR. I reached PCRU in 7 months on Tasigna and in a few months it will almost be two years of consistently negative PCRs.

I believe my onc is open to discussing a half dose or Tasigna (currently 300 2x per day). How would one best split the dosage with its 16 hour half life. Take two pills in the AM or one in the AM and one in the PM?

Anybody know or currently doing this?  Thank you.

#2 Trey


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Posted 24 February 2013 - 12:40 PM

I take 200mg Gleevec daily and do not split this low dosage.  I would not recommend splitting low dosage because it might dilute the effects to some degree.  I take them whenever I want each day, not always the same time of day, but always with food.  As for half-life, it remains the same (about 18 hours) just lower dosage in the body.

#3 Lori's okay

Lori's okay


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Posted 28 February 2013 - 10:46 PM


I'm currently on a half dose of Tasigna because I could not tolerate the full or a three quarter dose.  I take 150 in am and again in pm.  The oncologist asked how I was taking it and agreed with this dosage schedule.  We did not discuss it explicitly but my assumption was that she did not want times of very low levels if I just took it once a day....but that is an assumption on my part.  Because Trey knows his stuff I'll probably call and check with her to make sure.  Good luck!

By the way, I reached PCRU in September after taking T for 10 months.  We are hoping I can maintain it at this dose.


DX 09-2011 PCR 8.08 not IS WBC 17 , Began Tasigna 600mg  

in 2012 Tasigna 450mg/day ,in 2013-2017 Tasigna 300mg/day


09-11/ 8.08 not IS

03-12/ 0.054 not IS

06-12/ 0.035 not IS

09-12/ PCRU, 01-13/ PCRU

4-13/ 0.042 IS

7-13/ 0.014 IS

11-13/ PCRU, 04-14/ PCRU

8-14/ 0.006 IS

PCRU: 12-14/ 05-15/ 10-15/ 02-16/ 

09-16/ 02-17/ 09-17/ 

10-17 tapered off 

11-3-17 Stopped Tasigna

1-15-18 still PCRU


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