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DNA vaccine for leukemia has early positive results

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#1 random


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Posted 05 January 2013 - 12:47 PM

Hi everyone,

A HAPPY New Year!

Missed a while, because it seems my country has been banned from accessing this forum.

Received the error:


You don't have permission to access /community/bloodcancer/livingwith/cml on this server.

Bad idea anyway, because I will make things look like I'm posting from another country

So, how are you, how's everyone doing?

I've found a link and I thought will be useful: http://www.oncologyn...rticle/274314/#

I wonder what's the opinion of Trey & Co

Please feel free to comment!

#2 Trey


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Posted 05 January 2013 - 02:39 PM

Several different studies into CML vaccines using WT1 have been done starting in 2003.  They all show that if you inject someone with this specific WT1 DNA it stimulates T-cells to act against that injected DNA.  But it has not been shown that T-cells can be trained to recognize the somewhat larger amount of WT1 that is found in leukemic cells (compared to normal WBCs) and kill such cells, which would be the goal.  So maybe it has promise, but it has not yet been demonstrated to be effective against CML.

We have discussed the issue before on several occasions:


Here is the original clinical trial information for the study you reference:


#3 random


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Posted 06 January 2013 - 05:42 PM

Thanks Trey for the valuable info.

PS: seems that feedback from patients can be found here: http://www.cmlsupport.org.uk/node/7193

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