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University of Pennsylvania gene therapy shows promise in eradicating some blood cancers


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#1 Cliffee

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Posted 10 December 2012 - 04:54 PM

God Bless these researchers and scientists!

http://www.philly.co...od_cancers.html



#2 scuba

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Posted 10 December 2012 - 05:18 PM

I corresponded with Dr. Carl June regarding his novel T-cell research last year when I first read about his research and when my dog developed Lymphoma. He helped me to work with Texas A&M Vet clinic to culture my dogs cells to try in the dog what is being done in humans. In my case, my dog was going to be a test for changes they were making to the treatment protocol which I was only too happy to agree. Unfortunately, my dog's aggressive Lymphoma killed her before they could culture enough cells. They needed six to 12 weeks and she was gone in four.

During this process, I asked Dr. June could he not use the same technique on CML. He told me that in principle it should work, the mechanisms are very similar, but that it would be a long time before they would ever get there because the current treatment for CML is so successful. The diseases he is working with are those for which there is little hope and a breakthrough gives added life. And there are also side affects that are permanent. The type of cell that is attacked (in the article, they are malignant B-cells) gets destroyed - all of them. So there are no more B-cells. Fortunately other cells in the body (NK-cells, etc.) can do some of the work, but who knows if you can truly live without B-cells. The new T-cells are engineered to kill - B-cells, cancer and all.

What's truly exciting about the research and therapy is that it is near instant cure. In three weeks - the body's own T-cells destroy every cancer cell. Imagine a cancer therapy - you go in and a month later you are cured. A true cure. Even if the body re-develops the cancer, the T-cell is there to get it.

They're getting closer.


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#3 Sneezy12

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Posted 10 December 2012 - 05:57 PM

One may be able to live without functioning B-Cells-e.g. Bruton's Agammaglobulinemia. Since the various Gamma Globulins which produce antibodies are not adequately produced, injections of them and antibiotic treatment are needed indefinitely. Frank



#4 CallMeLucky

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Posted 10 December 2012 - 08:05 PM

Which begs the question if a life on Immunogobulins and antibiotics that much different (i.e. better) than a life on TKI drugs.


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 





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