3 replies to this topic

[Sneezy12]

http://bloodjournal....bstract?papetoc       Frank

[djm]

I read it, but don't understand it.  Can anyone give me a "laymen" version?

[Trey]

Occasionally (10% of kinase mutations) are compound mutations where there are multiple changes in the docking port for TKI drugs rather than a single change.  These are obviously more difficult to overcome and also to detect.  Knowing this is of little value.  Either the next drug works or it does not.  If one drug stops working, try another.  Most of the time one of the drugs (including non-approved drugs such as Ponatinib) will work. 

[Trey]

Those who liked Sneezy's article might also like to read the following (which also happens to be co-written by PhilB's pet squirrel, Herodotus)

Last I saw Herodotus, he was not dressed in such finery:

                                   PhilB's Pet Squirrel 

                                   (aka "Jive Genius")