Jump to content


Photo

Mutations Article


  • Please log in to reply
3 replies to this topic

#1 Sneezy12

Sneezy12

    Advanced Member

  • Members
  • PipPipPip
  • 67 posts
  • LocationMinnesota

Posted 06 December 2012 - 07:16 AM

http://bloodjournal....bstract?papetoc       Frank



#2 djm

djm

    New Member

  • Members
  • Pip
  • 0 posts

Posted 06 December 2012 - 09:08 AM

I read it, but don't understand it.  Can anyone give me a "laymen" version?



#3 Trey

Trey

    Advanced Member

  • PS Beta Group
  • PipPipPip
  • 1,705 posts
  • LocationSan Antonio, Texas

Posted 06 December 2012 - 10:36 PM

Occasionally (10% of kinase mutations) are compound mutations where there are multiple changes in the docking port for TKI drugs rather than a single change.  These are obviously more difficult to overcome and also to detect.  Knowing this is of little value.  Either the next drug works or it does not.  If one drug stops working, try another.  Most of the time one of the drugs (including non-approved drugs such as Ponatinib) will work. 



#4 Trey

Trey

    Advanced Member

  • PS Beta Group
  • PipPipPip
  • 1,705 posts
  • LocationSan Antonio, Texas

Posted 06 December 2012 - 10:59 PM

Those who liked Sneezy's article might also like to read the following (which also happens to be co-written by PhilB's pet squirrel, Herodotus)

The Essential Book of Useless Information: The Most Unimportant Things You'll Never Need to Know (The New York Times Bestselling)

Last I saw Herodotus, he was not dressed in such finery:

drunksquir.jpg

                                   PhilB's Pet Squirrel 

                                   (aka "Jive Genius")






1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users