Hi everyone,
I'm curious what other CMLers would do in my situation. Short story - I saw an upward trend in PCR on Gleevec 400mg, freaked out, pressed for a 6-week re-test, and it came back with the exact same result. Right at the edge of MMR. Ugh -- so close, yet so far. Trend since starting treatment in April 2011:
Non - IS
- July 2011 (3 months): 1.5%
- Oct 2011 (6 months): 0.16%
- Jan 2012 (9 months): 0.02%
- April 2012 (12 months): PCR-u
IS
- July 2012 (15 months): 0.043%
- Sept 2012 (~ 18 months): 0.124%
- Nov 2012 (~ 19 months): 0.125%
FISH was negative, so I'm CCyR and get to live for now. Doc has zero concern, says I'm doing great, stay the course on 400mg, and next PCR in April 2013. I have zero side effects from the dosage (that I can tell), so Gleevec is definitely playing well with me from that standpoint. But it's only able to beat down my CML to the edge of MMR apparently, despite flirting with a deeper log reduction initially. But CCyR is the primary indicator for survival - so I get that.
Just curious - what would others do in my situation? Stay the course and forget about it? Request for 600mg upgrade, since I haven't had tough side effects and see if I can beat it down further? Switch TKIs and surprise my CML and try to beat it down further that way? Stop drinking wine (not an option )? I feel and look perfectly healthy, so it's still mind boggling that this nasty CML thing is lurking inside me...
Thanks for any input -