I was diagnosed in January 2011 and after a little over a year on Gleevec, with plenty of pesky (though not severe) side effects, I switched to 100 mg Sprycel. Sprycel has been much better for me in terms of ability to concentrate and I don't have those annoying GI symptoms on it. But I have not had much improvement in terms of muscle pain, (perceived, at least) muscle weakness and the like.
My sister is a doctor and she is pushing me to start taking Cymbalta (duloxetine), an antidepressant that is approved for chronic low back and osteoarthritis pain and appears to act by interfering with pain signaling. (I do have low back pain but also pain pretty much everywhere else and I don't have osteoarthritis.) I am wary of adding another medication, especially since anti-depressants can cause lightheadedness and other symptoms similar to some symptoms I have struggled with, possibly as a result of TKI-induced endocrine disruption. At the same time, however, it is hard to imagine feeling like I am 85 years old indefinitely (my actual age is 45!)
Have any of you been on Cymbalta for musculoskeletal pain or fibromyalgia? How effective was it and did you have significant side effects?
Thanks for any advice--