Hello everyone! Got a new plan...will be starting on Bosutinib as soon as my ANC return to normal. Had a visit with Dr Cortes at MD Anderson. After BMB results showed minimal response to the low dosage of 125 mg of Tasigna and the supplement of Neupogen shots to maintain my ANC above.5 that I was on, we have determined to try Bosutinib, since it has shown to be less myeloid depressive. New plan is to start on 400 mg of Bosutinib, slightly less than the 500 mg normal dose, once my ANC are above 1.0. Currently ANC are .4, but should be better soon now that I'm on break. Once I've started Bosutinib, will do weekly labs, supplement with Neupogen shots as needed, and test at 3 and 6 months for response levels. Interesting to note that he doesn't want me to reduce dosage or take drug break if my ANC drop again, but to start shots again. That's not the normal protocol and need to inquire about his reasoning on that more.
If this fails, then will likely need SCT. Ponotinib will probably not be an option since it has not proven to be less myeloid depressive. Dr. Cortes will coordinate with my local Dr here in Arizona.
So...I come to ask what people have experienced on Bosutinib. I've read all the data, but would love to hear from real people.
Will enjoy my break from drugs and shots, along with the beautiful fall weather we're having. I'll take this time and get started exercising again and pray that Bosutinib is the drug for me. Praying always for everyone here and hope everyone is enjoying the Fall!
Best to all!