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Can Tasigna cause neuropathy?


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#1 cmlquestions

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Posted 11 October 2012 - 07:00 PM

I'm currently on a 150mg twice daily dosage of Tasigna (dose reduction due to a variety of side effects and good response to treatment). Over the past month or so, I've been having a new symptom and am wondering whether or not it's drug-related. It started as a cold, tingling sensation felt in random places on my arms, legs, and face. It's becoming increasingly bothersome and chronic, interfering with sleep. I'm now also getting a pins and needles/falling asleep feeling in my hands, feet, and left side of my face. I saw a headache specialist/neurologist earlier this week, and he thought it was most likely a sensory aura related to my migraines. However, with the symptoms worsening and becoming more constant, I am wondering if it could be neuropathy caused by the Tasigna. I had an MRI of my head several months ago which was pretty much normal, a normal neuro exam Monday, and normal thyroid tests a couple months ago. I see my hem/onc tomorrow and should get the results back then on my BCR/ABL (my result a month ago was 1 cell positive per 100,000 / .001%). I am curious if anyone has any thoughts on this. I saw a few things on the internet suggesting it could be a side effect of the drug, and while I don't want to overreact, I want to take this seriously if the Tasigna is causing nerve damage.

Thanks!



#2 Trey

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Posted 13 October 2012 - 06:21 PM

The CML TKI drugs can cause neuropathy.  Sprycel seems to be the worst offender, then Gleevec.  I have not seen as much about Tasigna causing it, but there is no reason to doubt that it can.  But it is not nerve damage.  It is signal interference. 

Previous posting on PN:

http://community.lls.../message/141289



#3 bagdaddi

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Posted 15 October 2012 - 01:19 PM

On same dose of Tasigna, developed similar tingling symtoms around the four month point that continues today (seven months).  Mine is isolated to my right arm - tingling from the shoulder to the fingers.  More of an annoyance than anything else.  I considered trying Alpha Lipoic Acid Supplements to see if that would help ( based on similar discussions/advice from others), but haven't tried it yet.  It is a readily available, inexpensive supplement that seems to help some people. 






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