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Can Tasigna cause neuropathy?

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#1 cmlquestions


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Posted 11 October 2012 - 07:00 PM

I'm currently on a 150mg twice daily dosage of Tasigna (dose reduction due to a variety of side effects and good response to treatment). Over the past month or so, I've been having a new symptom and am wondering whether or not it's drug-related. It started as a cold, tingling sensation felt in random places on my arms, legs, and face. It's becoming increasingly bothersome and chronic, interfering with sleep. I'm now also getting a pins and needles/falling asleep feeling in my hands, feet, and left side of my face. I saw a headache specialist/neurologist earlier this week, and he thought it was most likely a sensory aura related to my migraines. However, with the symptoms worsening and becoming more constant, I am wondering if it could be neuropathy caused by the Tasigna. I had an MRI of my head several months ago which was pretty much normal, a normal neuro exam Monday, and normal thyroid tests a couple months ago. I see my hem/onc tomorrow and should get the results back then on my BCR/ABL (my result a month ago was 1 cell positive per 100,000 / .001%). I am curious if anyone has any thoughts on this. I saw a few things on the internet suggesting it could be a side effect of the drug, and while I don't want to overreact, I want to take this seriously if the Tasigna is causing nerve damage.


#2 Trey


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Posted 13 October 2012 - 06:21 PM

The CML TKI drugs can cause neuropathy.  Sprycel seems to be the worst offender, then Gleevec.  I have not seen as much about Tasigna causing it, but there is no reason to doubt that it can.  But it is not nerve damage.  It is signal interference. 

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#3 bagdaddi


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Posted 15 October 2012 - 01:19 PM

On same dose of Tasigna, developed similar tingling symtoms around the four month point that continues today (seven months).  Mine is isolated to my right arm - tingling from the shoulder to the fingers.  More of an annoyance than anything else.  I considered trying Alpha Lipoic Acid Supplements to see if that would help ( based on similar discussions/advice from others), but haven't tried it yet.  It is a readily available, inexpensive supplement that seems to help some people. 

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