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Coffee may help to fight CML? How much coffee do you drink daily?

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#1 cousineg


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Posted 06 October 2012 - 03:58 PM

A liltle survey to determine if drinking coffee help to fight CML:


How Much Coffee Do You Drink Daily?

Are you PCRU (PCR undectable)? How long?

When do you take your medication (Gleevec or else)? When do you take coffee?


Coffee contains hundreds of components including substantial amounts of chlorogenic acid, caffeine, magnesium,
potassium, vitamin B3, trigonelline, and lignans. ...

Mechanisms which might contribute to a possible anticarcinogenic effect include reduction in cholesterol, bile acid and neutral sterol secretion in the colon, increased colonic motility and reduced exposure of epithelium to carcinogens, the ability of diterpenes to reduce genotoxicity of carcinogens, and lower DNA adduct formation, and the ability of caffeic acid and chlorogenic acid to decreased DNA methylation....

Extract of Moderate Coffee Drinking Reduces Many Risks, Panel Says


See Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells.

#2 Badger


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Posted 06 October 2012 - 07:23 PM

Great! All I have to do is drink coffee and eat wheat grass and I can ditch the Tasigna!

#3 mariebow



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Posted 06 October 2012 - 08:11 PM

Badger you know it. lol

#4 ChrisC


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Posted 06 October 2012 - 09:47 PM

Yummm, I have one cup of coffee here at home in the morning. Sometimes made by using a French Press, sometimes by espresso machine, sometimes by stovetop stainless steel espresso maker, sometimes by ceramic Melitta drip with unbleached filter: all from fresh, locally roasted, Fair Trade, dark roast beans, ground at home (friends own a local coffee roasting company, and they also supply three local Whole Foods stores with these same beans — very handy!). It is indeed the little things in life that bring one joy, and we bring our joy to it, too! We all have our areas of appreciation, and I am glad that good coffee is available. (I have had very good luck shopping the resale stores for used coffee equipment: never spent more than $7.00 for any of these excellent coffee makers!)

There are questions re the benefits from drinking coffee that entirely filters out the fine particles, and those that don't, so I vary the equipment and enjoy each one

Oh yeah: I became PCRU within 11 months of dx, have been PCRU for just over three years, and have been entirely off my TKI (Sprycel, after being intolerant of Gleevec) for just over one year.

It works for me!


Message was edited by: ChrisC

Be alert, but not overly concerned.


• Dx Oct. 22, 2008, WBC 459k, in ICU for 2 days + in hospital 1 week

• Leukapheresis for 1 week, to reduce WBC (wasn't given Hydroxyurea)

• Oct. 28, 2008: CML confirmed, start Gleevec 400mg

• Oct. 31, 2008: sent home when WBC reached 121k

• On/off, reduced dose Gleevec for 7 months

• April 2009: Started Sprycel 100mg

• Sept. 2009: PCRU 0.000

• Sept. 2011: after 2 years steady PCRU & taking Sprycel 100mg before bed, quit Sprycel (with permission)

• Currently: still steady PCRU, testing every 6 months 🤗

— Fatigue, hearing loss continue, alas, but I prefer to think it is all getting better!



#5 scuba


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Posted 07 October 2012 - 09:16 AM

... and just when you thought coffee might be good for you, this comes out:


(I still enjoy my 3 cups of Italian dark roast every day)

Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein


Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.


2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"

#6 NotJack?


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Posted 07 October 2012 - 10:20 AM

Hey Badger,

I know that my source is not as reliable a source as the internet, but I asked an experienced bartender if a pint of Guinness a day could cure CML, and he said that he wouldn't be surprised!!  So feel free to add that to your holistic intake,  I know that I will.


#7 cousineg


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Posted 07 October 2012 - 10:52 AM

Thank you Scuba for this article about glaucoma with coffee. In this article, I noted this passage:

''That was corroborated by knowledge that caffeine affects levels of homocysteine in our eyes, and that homocysteine levels are often high in people with EG (exfoliation glaucoma)''

So we have to reduce the caffeine and increase the chlorogenic acid.


Evaluation of caffeine in coffee

A moderate dose of caffeine is 200-300 mg a day. Here's a good gauge to measure your caffeine intake: a cup of coffee has 100-200 mg, a cup of tea has 40-120 mg and a soda has 20-80 mg.

Extract of Caffeine Detox Challenge


The green coffee bean supplement has only around 20 mg of caffeine per serving, whereas your daily cup of coffee has over 100 mg (and your "venti drip" has as much as 400 mg). Green coffee bean is not a stimulant; it doesn't make you jittery and nervous and raise your heart rate like roasted coffee or ephedra. In fact, the green coffee bean has actually been shown in some studies to help lower blood pressure -- while still boosting metabolism.

Extract of How much caffeine is in green coffee bean supplements

#8 everonward


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Posted 07 October 2012 - 11:44 AM

The only thing coffee does for me these days is increase the shart attack.  I still have the occasional espresso caus I love it but boy do I know about it afterwards

#9 Antilogical


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Posted 07 October 2012 - 05:08 PM

Oh, dear.  If I had to choose, I'd choose the coffee, sharts and all.  I'm sure that my "real" friends would stick by me, albeit outdoors and upwind.....


Dx: Sudden severe anemia detected 07/2011, followed by WBC spike. CML Dx 02/2012.

Rx: 03/2012-Gleevec400.  Reduced 02/2013 to Gleevec300 due to side effects (low blood counts).

Response: PCR-Und within 7 mo. on G400. Maintained MMR4-MMR4.5 on G300. PCR-Und since 02/2016.

#10 Badger


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Posted 07 October 2012 - 05:54 PM


I immediately took your advise and downed a point, and then another just to be on the safe side. Don't know what it did for my cml, but it did make me forget that I had it (at least for a while).

Thanks for the advise.

#11 Guest_billronm_*

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Posted 07 October 2012 - 06:01 PM

Hi Gilles,

  I used to drink coffee all day, I enjoy a good cup of different kinds, this stupid acid reflux took that enjoyment away from me. I'm only allowed one cappacino a day it turns me into a motor mouth, even decaf. So all I can handle is 2 cups in the morning.

  Years ago my sister and I had an appt. with a lawyer. Before I left home I asked her if she needed anything, she said to pick up a cup of cappucino for her. I had never had that before so I got 2 large ones and started sipping on it. I live 10 miles out of town so I did a lot of sipping, I picked my sister up and she started sipping too. By the time we got to the attorneys office we both had such a caffein,sugar buzz we couldn't stop talking. Luckily he was a friend of my sisters husband  so he took care of our business, but he probably would have thrown us out if he wasn't a friend.

Words of wisdom, Never drink Cappucino before going to your attorny, or going to confession!    Billie

#12 NotJack?


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Posted 07 October 2012 - 06:16 PM

There have been many studies, and many a masters thesis on the benefits of a good pint of Guinness.  Here are several justifications for imbibing in the ruby colored elixer -- (just in case you needed the excuse) : http://news.bbc.co.uk/2/hi/3266819.stm      and    http://bogerk.hubpag...ss-Good-For-You     Bottoms up!! 


#13 Susan61


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Posted 07 October 2012 - 06:40 PM

HI:  I have been a very heavy coffee drinker since I was a teenager, and still love my coffee to this day.  I drink it morning, afternoon, and some evenings with my husband before he goes into work for his night shift.  The only problem I have had is with the night coffee that keeps me up watching Jay Leno at 11:30, and having trouble falling asleep.  I have not had a GERD problem as long as I take my Nexium.

    Who knows what anything does to us in a positive or negative way anymore.  Glad to see your sense of humor Billie, as I still think that is the best form of medicine we could all use to cure whatever ails us.


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