I have some questions about my latest RT-PCR results. I had to go with LabCorp and not Quest this time as my insurance changed the lab that is in network. The format of the results changed and so I am unable to make sense of the new results.
Here are the results:
1. b2a2 transcript: 0.192
2. b3a2 transcript: 0.136
3. e1a2 transcript: ------
4. <0.001% (Sensitivity limit of assay)
Transcripts: First of all, what are b2a2, b3a2 and e1a2. I have never seen this in my Quest reports. What do those numbers against the transcripts (0.192 and 0.136) signify? I do not see any reference values and hence I do not know if this result is good or bad. I do not have past results reported at the transcript level, so I cannot compare the data to see if my condition has become better or worse.
Log Reduction: The report says that the standardized baseline is 100% BCR-ABL. So I think this represents 5 log reduction or more--Is this correct? The previous RT-PCR results (done in August 2012) indicated 3.014 log reduction. From this perspective I think that I am doing well. Does 5-log reduction represent PCRU or MMR (Major Molecular Response)?
Other Details: DX in 11/2009. On Gleevec from 11/2009 to 1/2011. On Tasigna since 1/2011.