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Latest CBC results question

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#1 djm


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Posted 28 August 2012 - 10:55 AM

Hey everyone,

I've just received my latest CBC results and if I could get some feedback on these results, I'd be grateful.

Latest (8/21/12)

WBC - 9.8  (3.8-10.8)                                      

RBC - 3.46 (4.2-5.8)                                        

Hemoglobin - 11.2 (13.2-17.1)                             

Hematocrit - 33.7 (38.5-50)                                  

Absolute Neutrophils - 5664 (1500-7800)              

Absolute Lymphocytes - 2803 (850-3900)       

Absolute Monocytes - 1029 (200-950)                     

Absolute Eosinophils - 274 (15-500)

Absolute Basophils - 29 (0-200)

1-Month Prior (7/24/12)

WBC - 7.6

RBC - 3.49 (4.2-5.8)

Hemoglobin - 11.6 (13.2-17.1)

Hematocrit - 34.7 (38.5-50)

Absolute Neutrophils - 4446

Absolute Lymphocytes - 2440

Absolute Monocytes - 502

Absolute Eosinphils - 160

Absolute Basophils - 53

I was on 600mg Gleevec and switched to 800mg Tasigna (400mg twice a day) after my 3-month PCR was 3.4% down from 29.3% and my FISH was 13% down from 96%.  I switched on 8/6/12.  So, the latest CBC shows almost 3 weeks of Tasigna.  I'm not as concerned about my Red blood cell, hemoglobin, and hematocrit, as these have been steadily getting better since diagnosis.  However, this is the first time that they have regressed so maybe I should be concerned about these numbers.  I am concerned about all the White blood cell counts.  All of them have increased, even though they are still within the normal range, except for the Absolute Monocytes.

Is this typical behavior of Tasigna upon being switched to it?  I honestly thought I would see much lower whilte blood cells and wasn't at all expecting to see higher numbers.  Hopefully this is nothing I need to worry about.  I am getting really tired of the constant worrying...

My next appointment with my onc is in a month.



#2 Sneezy12


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Posted 28 August 2012 - 11:22 AM

Looks fine, but why were you switched from Gleevec since you were doing well? Regards, Frank

#3 djm


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Posted 28 August 2012 - 11:35 AM

Well, two things.

1. I was developing some pretty bad edema on Gleevec (puffy face, neck, ankles) and she felt switching would be good.

2. My onc is a perfectionist and she really wanted a zero FISH.

I don't mind being switched, I just get real jumpy when I see numbers start going a little higher.

#4 Trey


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Posted 28 August 2012 - 05:26 PM

The FISH and PCR numbers are going in the right direction, so that is the important issue.  The WBC and monocytes may show some other immune response issue was going on at the time, something unrelated to CML.  You should have another CBC done within about 4 - 6 weeks from that last one to check on it.  These things happen, but most people never realize how much their blood counts jump around on a regular basis.

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