SMO Hedgehog inhibitors have shown some promise in CML, but have mainly been tested on solid tumors. The clinical trial for CML using Sprycel + SMO Hedgehog inhibitor has been ongoing for 2 years and has not yet enrolled the 36 patients they had hoped to get, so it has apparently gone a bit slow, and there is no preliminary report out. I have not heard anyone discuss being in the trial. I'm sure they would like to get some more participants, so this is a chance to be part of this if you wish. Clinical trials are a chance to push the edges of the envelope in drug development and potentially make a difference. Phase I trials generally have the highest risk of clinical trials, so get all the info first, but there have been quite a few trials using the drug on solid tumors, so the safety profile should be reasonably established. The combo trial has been suggested as a potential "cure" for CML, so at least some of us would like to see you in the trial. So it would be interesting to watch you do this, but "interesting" to an observer is not the same as "participating". Overall it sounds like a reasonable plan, and Dr Talpaz would watch you carefully.