I posted a question back in March of this year about resuming treatment on Tasigna, but at 450mg once daily after a seven-month break from treatment due to a variety of side effects on the normal dosage of Tasigna, followed by bad reactions to two single doses of Sprycel.
I had lost MMR prior to resuming treatment, but after less than three months on the new dosage, my BCR/ABL is "undetectable" for the first time! That is awesome news for which I am extremely grateful, and the once daily dosage schedule is certainly much easier to deal with. The only problem is that many of my side effects have returned, and I am now having chronic, severe headaches. I do have a history of migraines and TMJ issues that I'm sure are influencing the situation, but the headaches were not so much of an issue when I was on 300mg twice daily.
I am wondering now about cutting the dosage back further to 300mg once daily, or 150mg twice daily. I am also wondering about "pulse therapy", or alternating periods of time on & off the drug to give me a break from the side effects. My plan was to make it another two years at undetectable, then try coming off indefinitely, but these awful headaches are forcing my hand to make another change. My hem-onc is looking into these matters, but since it's taking a while to hear back from him, and I'm feeling pretty miserable, I thought I'd see if anyone here has any info or opinions?