"So your Onc saw that you did not respond very quickly to 400mg, put you on 600mg, then back to 400mg (and no side effects issues)?"
Upon dx, I started with 400mg Gleevec and 2000mg Hydrea. With that, I had very little or no drop in WBC , so we temporarily went with 600mg and 4000mg for two weeks until hematologic response and a WBC of 3900. Then back down to just the 400mg standard dose of G for the next two months until my recent FISH test. The results were so unexpectedly poor that he doesn't even want to try the 600 again, unless the 800 makes my counts drop too much or if the side effects are too severe. We're going up to 800mg for the next month and then another FISH test. After that, "I'll almost certainly be going to Sprycel unless the 800mg puts a huge dent in the numbers," says the doc. He said sometimes he would be patient, but not in my case. He doesn't think Gleevec is for me anymore. This next month is just to put all doubts to rest. I'll be the first patient of his that hasn't had a perfect response to the G. That's a damn shame. I feel better than I have in at least a year while taking Gleevec. Even the 800 is a breeze. I just hope Sprycel is half as easy.
BTW, thx again for the consults.