5 replies to this topic

[stephiericks]

I apologize because I know I have this info somewhere detailing how to interpret BM results - can't find on this new iPad and am excited to understand them! My husbands results were just posted on mymdanderson.com.... What does this mean please?

46,XY, t(9;22)(q34;q11.2)[3]

And

Diploid male karyotype 46,XY [17]

And

The percentage of BCR-ABL to ABL transcripts is 3.48

Thank you thank you thank you!,

[Happycat]

Steph,

Not an expert, but will take a stab at it.

46 XY t 9,22, q....(3). -  sorry too lazy to type it all out. Those are cells that show the typical translocation in chromosomes 9 and 22.  The q34 stuff just pinpoints where on the chromosomes the turns locations take place.  The number 3 in brackets means 3 of the cells showed the translocation. This is a classic cml translocation.

The other 46 XY (17) just means that 17 of the cells examined had a normal chromosome pattern for a male.

The 3.48% bcr-abl to abl means there are 3.48 leukemic CML cells (bcr-abl is the oncogene that causes cml) for every 100 normal cells (abl gene). Since it says percent, I'm assuming they really mean percent.

HTH,

Traci

[Happycat]

Dang!  Writing on an iPad, too, and sometimes that autocorrect typing feature really annoys me. Translocations not "turns location". Stupid iPad thinks its smarter than me. Maybe it is, but I know how to spell and type.

[stephiericks]

Thank you Traci - just made our night! Looking forward to discussing with Dr. Cortes

[PhilB]

Just one little point, the BCR-ABL trancripts bit is a PCR test so separate from the main cytology numbers.  In terms of cells with the translocation they found 3 out of 20 which is 15% - a nice solid, partial cyctolgenic response.

The 3.48% PCR isn't particularly meaningful at thios stage - it's just the number you watch once the first one its 0 / 20

[Floa7]

Phil that answered a lot of questions for me. I go for my first 3 month BCR-ABL this Friday the 25th. I will understand the doc when I get the results, to see how far down the scale I have come. Thanks