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#1 JoshLee



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Posted 14 May 2012 - 05:30 PM

Hi All,

     I just got a call from my oncologist and wanted to see what you all thought about this. As some of you may know, I have been stalled out on Tasigna, so my oncologist wanted to try increasing my dosage from 600 mg daily to 800 mg daily. We are testing once a month, (April3rd and now May 3rd) but this time we sent out two PCR's at the same time. One to Mayo and one to Blood Center of Wisconsin, where I usually get tested. I know you cannot compare labs, but this is kind of a big difference. My log reduction at BCW went from .9 to 1.2 log reduction in a month and my test at Mayo, which is done using the international scale came back with a 1.3%, which corroborates my CCyR, which from what I understand is a 2 log reduction. At one lab, I have a 1.2 log reduction and at another lab I have a 2 log reduction. The mayo lab uses ABL as the control and the other lab uses G6PDH. I know with PCRs, you look for trends, but this still has peaked my curiosity. 

#2 scuba


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Posted 14 May 2012 - 06:12 PM


Apples - Oranges. Pick one lab, one control gene and stick to it. All else is irrelevant.

You want to develop a trend that is meaningful. Comparing results from two labs using two different control genes is meaningless.

Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein


Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.


2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"

#3 Trey


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Posted 14 May 2012 - 09:26 PM

That is a big difference.  Shows why PCRs from different labs should not be directly compared.

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