I have been pleased with my Sprycel response and take Curcumin and all that, however:
"Despite the recent success of tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML), approximately 2-17% of patients develop clonal cytogenetic changes in the Philadelphia-negative (Ph?) cell population. A fraction of these patients, in particular those displaying trisomy 8 or monosomy 7, are at risk of developing a myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML)."
I did develop cytogenetic changes in my normal cells (non-Philadelphia + cells) along the lines described in this paper - specifically trisomy 8 and Monosomy7 at my last bone marrow (Dec 2011). Dr. Cortes tells me the risk of developing MDS is small but not zero and that "we watch" (which means more bone marrows despite my MMR). I do wonder what causes this - either the Sprycel itself or just a defective blood system. My CBC does show persistent anemia (25% less red blood). I don't know if they see this with Gleevec patients.
So even though Sprycel has been a great addition to the TKI mix, there is still a lot not known in comparison to Gleevec. It simply has not been in use as long. I would love to learn if there is any research to the contrary regarding Sprycel and cytogenetic effects on Ph- cells.
Anyone else have trisomy8 or Monosomy7 in their bone marrow reports? (especially anyone taking Sprycel?)