I so appreciate your post. I hope you retain your 3 log reduction. Do you know what range will be acceptable before your onc would prefer you went back on 300mg? Where or who is your oncologist?
Humm ANC what is normal range? How long has yours been low? I would think on 200mg it would come back up, or is that going to be a permanent thing. See that is what I have been trying to watch on this board?? On these side effects of TKI's what becomes permanent damage and could they have been avoided on a lower dose.
Sometimes I hate to post as some, are so against lower the dose, thinking they will live longer, or they will have mutations. I can't imagine get upset over a .001 to a .01 or whatever!! I think the fear of just being diagnosed, especially new people, some doctors scare the BG'S out of you. The unknown is scary. Not that it isn't serious disease, but is it really necessary to take such drastic measures, then have all these other additional health issues. TKi may be a targeted drug but they are still very toxic to the whole body.
I think it is even more important to stay at the lowest dose you possible can, as to give your organs a rest and to function as normal as they can. Chemicals take such a toll on our body, if not now, long term side effects could leave us with a poor quality of life. I not in a hurry to die, but not much fun when you have a lot of limitations. I mean you take one drug for something then you have another problem, then you take another drug and it gets to be a vicious cycle of juggle meds, labs, side effects and your whole life becomes about cancer. Not only that but even if you are undetectable you still have millions of CML cells. So I have come to the conclusion that the lower the dose and keep your CBC counts to as close to normal as you can while keeping the CML counts in a stable range would be the most I could hope for.
I can only dream of being on 200mg of Gleevec. I recently changed onc and have only had one lab, it was not that I would be able to lower dose. My previous onc sent my blood labs out of state for 6 years and I was PCRU until last year, but it turned out the lab had changed over to the IS. In fact it was me calling the lab and LLS as my doctor was freaking me out to change drugs. Mind you had been on Gleevec for 6 years. To my knowledge it was not anything that had changed regarding my CML or Gleevec but the lab testing. So I was not near as upset as my onc was. Anyhow I found out that INdiana Univ Cancer center does there own labs and interpretation. I have only had one set of labs the next labs are not due until June. Hopefully I will remain in a stable range. I am not overly concerned to be PCRU as long as the numbers are stable. I recently went to a seminar and the onc said it is OK to even have labs in a wave, as you can have 12 different labs and 12 different results.
I am anxious to see how you do on the 200mg. Wow 3 long reduction in 4 months.
Best of wishes, PamSouth