FISH BCR Speci^1,2/14/2011 03:15 pM Bone Marrow
F I SH BCR Or d e r I 2 / L 4 / 2 0 1 1 0 3 : 1 5 pM 1 5 De c 2 0 1 _ 10 8 : 0 3
FISH BCR MethodL2/L4/2011 03:l-5 pM (NoTE)FISH for the ABL oncogene and BCR (breakpoint cluster
region) ,
FIsH BcR Reason1"2/L4/2011103 :15 pM chronic myel_ogenous leukenia/cML
FISH BCR p'esul-EL2/L4/2011 03r1"5 PM (NOTE)nuc ish(ABLX3), (BCRX3), (ABL con BCRx2) t1915001
Of 500 nuclei, 3.8t had fusion of BCR and ABL signals. The
normal cutoff is <0.6t for 1 ABL, 1 BCR and 2 BCR/ABL fusion
Chrom BM SpecimL2/L4/2011" 03:15 pM Bone Marrow
Chrom BM Order L2/L4/ 2011 03:15 PM l_5 Dec 2Ol1 08:03
Chrom BM Band ML2/L4/2011 03:15 PM (NOTE)Method Analyzed Karyotyped Band Level
GTL
ToLal 20 3 400
Chrom BM MeL}lod],2/L4/201-L 03:15 PM Culture without mit.ogens
Chrom BM p.eason1"2/142/ 011r03:1-5 pM chronic myelogenous leukemia/CML
Ch r om BM Re s u l t 1 2 / 1 4 1 2 0 L L 0 3 : 1 5 PM 4 6 , x y , E ( 9 ; 2 2 ) ( q 3 4 ; q 1 " 1 - . 2t 3) l / 4 6 , X y l j - 7 1
Chron BM Interpt2/L4/2011 03:15 PM (NOTE)The result is abnorrnal. Of 20 metaphases, 17 were normal
and 3 had a t ( 9 i 2 2 ) ( q 3 4 ; q 1 1 . 2 ) . This t r a n s l o c a t i o n i s
consistenE wiEh CML. Landstrom Ap er al., Leuk Llmphoma
47 ( 3 ) : 3 9 7 - 4 0 2 , 2006; Kal_idas et a l . , JAMA 286:895-898, 2 0 0 1 .
FISH studies for BCR and ABL are pending (reported
separaLely) .
s i g n a ] s .
FISH BCR InterpL2/L4/201L 03:15 PM (NOTE)The result is abnormal and indicates BCR/ABrr fusion in 3,89
of nucfei. This resulE is consisEenL with L]ne L(9;22)
observed in the chromosome studies (reported separaEely).
This result is usually associated wit.h CML or precursor
B-ceLl ALL. Landstrom et a1. / Leuk L)mphoma 47:397-402,
2006; Kalidas et. at. , ,fAMA 286;895-898, 2 0 0 1 .