Well I'm upset to report that my pcr did not remain the same on the lower dose of Tasigna (450 MG per day). After one month of being on this lower dose it actually has risen, now it wasn't a significant increase but this is definitely not the direction we want to see. So my options are to either go back on the higher dose (300 MG X 2 daily) or try a different drug Sprycel (100 MG daily). I am inclined to raise my dose since Tasigna has worked so tremendously well for me.
Currently I am at 0.0023 30 days ago I was at 0.0007 so obviously staying at the 450 MG per day dose is not an option. I was dx in Nov of 2010 with a pcr of 1.9. I reached ccyr in 08/29/11 and MMR on 12/5/2011. I was suboptimal on Gleevec for the first six-months of that before switching to Tasigna which got me to MMR at 13 months. So overall I have had a very good success rate on Tasigna.
So the big question is do I go back on the higher dose of Tasigna or start a new TKI to see if I feel better? The reason I even tried the lower dose of Tasigna was due to side effects impeding my QoL. My doctors recommendation is to switch to Sprycel rather than staying on Tasigna even at the higher dose. She believes I could feel better on Sprycel despite knowing it comes with its own baggage.
What are you guys thoughts, Trey? Scuba?