I am a little tired and sleepy eyed, but you did write the;
>>BMB PH+ was 0 out of 30, and your FISH is .8 %m PCR fluctuated downward (insignificantly). and normal morphology.<<, right?
With those great number why would your doctor increase you Tasigna from 600mg to 800 mg and if no change in what you will be switched to Sprycel?
What am I missing? I mean PCR labs they can vary from 1 test to another, you know its like 1 drop of blood they test.
You can take a dozen different (drops of blood to be tested) PCR LABS and the test results would all be different .
I was very recently at a dinner by the LLS. One of the Leukemia experts said "as long as the PCR is not in a continual trend going up, that is Ok as you expect the lab test result to go in waves.
I am sure there would will be others who would disagree with me, but I personally would rely more on your BMB and FISH then a PCR. Again, unless that PCR is going up, up, up over time, then I would be calling the lab as well to see what is going on there.
PCR may be more sensitive and study thousand of cells but there is more room for error, as my previous oncology would say, "they are magnified over and over and there is lots of room for error." Even if you were PCR undetectable, you would still have a million or so PH+ cells. The PCR is only so sensitive it can't possibly find all of the PH+, your only testing a drop of blood our of how many pints?
I don't see the big deal, to up your dose, or change your meds.
Just wondering!! My opinion only. It would take a lot more then that for me to up my doze and switch drugs. Like what our the toxic effects of more meds, short / long term on your body. If you were to have adverse affects from a larger dose and have to take other pills to counter the effect.... well I don't necessarily think larger doze is better, with your numbers. I mean will you live longer, I think there are many theories and every one is different. Sometimes I think; Ok what is the magic numbers of; doze of TKI, good CBC, metabolic etc for my liver and kidneys and other organs. And the long term side effects of the drugs and quality of life. Will I live any longer if ??? I'm mean what is the combination??? Sorry just thinking out loud, that Dear God will they come up with a cure and we won't have to worry or fret or all this!!
Again Just My Opinion, I have no medical degree, just an opinion.