My husband's 6 month bone marrow test showed 50% still showed the Philadelphia Chromosome and his oncologist switched him from Gleevec to Sprycel. I posted about this a couple weeks ago and really appreciate the helpful responses. Unfortunately he has had severe reactions to the Sprycel in the two weeks he's been on it - last night he had a fever that got up to 103.5. He had major chills the first night on Sprycel and this past Monday that kept him shivering (with a fever) all night. His oncologist told him to stop taking the Sprycel for four days and he'll decide the best next move.
I know that ideally hitting complete response in one year is the goal and there are certain milestones to reach (like only 6 of 20 after 6 months, whereas my husband had 10). Are there some patients that it takes just a little longer with Gleevec? He had no side effects on Gleevec and we're concerned the doctor gave up on Gleevec too quickly. Isn't it possible he could have met the 70% reduction at 7 months instead of 6? We are confused about how this benchmark is determined - is it an average?
My husband thinks giving the Gleevec feels like the right move and giving it more time. What are your thoughts? Would you try the Sprycel again with the terrible reaction or move on to Tasigna? Also still waiting on the mutation results.....
We like our oncologist but he has only seen 10 CML patients and all but one did great on Gleevec and that one had success with Sprycel. We both feel its time to see a specialist - based on what I've read, Dr. Talpaz sounds like a great fit.
Was awful to see him with that horrible fever and he's so worried - your feedback is so comforting!