So every few months over the first year of treatment, I've been getting pain/inflammation in my lower right abdomen that has been quite an irritant. I started Gleevec 400mg in mid-April and I had my first flare-up in early June, then early October, very briefly in early January, and at the end of March (now). I had a couple of urologists check me out last year and they seem to think it's prostatitis, but I'm just not quite sure - it just feels like a "catch all" diagnosis. They prescribed antibiotics for the first two flare-ups (Bactrim DS and Doxacycline) that I took for about 10 days each time, and eventually the pain/swelling went away. However, the 2nd two flare-ups haven't been as bad and I haven't touched the antibotics at all. I did take 600mg Ibuprofen early yesterday (after running a fast 5K road race with some ankle swelling), and sure enough - the abdomen pain vanished for a good 7-8 hours ... presumably because of the Ibuprofen dose.
The other thing I've noticed is that the pain is non-existent when I wake up, and the "sensation" starts up ~ 3 hours after taking Gleevec. So now I'm wondering if they are directly related (or maybe related to gravity??) and if I should consider moving the dose to night, or splitting the 400mg pills and taking 200mg in the morning and 200mg in the evening. I do like to have red wine in the evenings, so the dosage split makes me nervous with 200mg Gleevec + some red wine at night. Would welcome some thoughts here, assuming I can continue to have a little bit of red wine at night.
Does anyone else get weird inflammation "episodes" like this, and is it attributed to an effect that the TKI has on our bodies? Perhaps it is non-bacterial prostatitis that is induced every few months from the effects of the TKI, but obviously I can't say for sure. Have any other men out here had this problem in this specific area of the abdomen? Admittedly, it's a terrible place to have pain/swelling and can be very distracting & discouraging for many reasons ... the Ibuprofen definitely worked, but I guess I need to assess the safety of 600mg of Ibuprofen every 24 hours for a couple of weeks while I get through one of these episodes.
Thanks for feedback regarding these episodes, thoughts on dosing changes/schedules, etc.